replaced bad coil pack and new coil not sparking car starts but runs rough engine light on blinks sometimes

Car started running rough while driving. tests revealed bad coil pack cyl 1&4. replaced coil still not firing now #6 not firing too. Car starts right up runs rough and even more rough when shift into drive or reverse engine light on and blinks when accellerator is pressed. Car has over 250000 miles but was rebuilt about 10 months ago. Car was operating fine and noticed gas milage began to decrease in last couple weeks this problem started 3days ago. Spark plugs and wires replaced about month ago. Would appreciate some direction to take troubleshooting or a diagnosis. Thank You.

My car

– replaced bad coil pack and new coil not sparking car starts but runs rough engine light on blinks sometimes